Microvascular Effects of Picamilon in the
[Article in Russian]
Institute of Pharmacology,
Baltiyskaya st., 8, Moscow, 125315, USSR
Picamilon when locally applied at a dose of 0,2 ml of 5% solution was found to induce the dilatation of pial arterioles.
The most pronounced dilatation was observed in vessels with the initial diameter of 10-20 nm. With arteriole diameter being increased the dilatatory effect of the drug diminished.
When differently administered picamilon causes the increase in cortex blood flow in conscious rats and rabbits.