Cerebrovascular Activity of Picamilon in the post Ischemic Period

[Article in Russian]

Pharmaceutical Institute, 
Kalinin's prosp., 11, Pyatigorsk, 357533, USSR

Abstract

Antihypoxic properties of picamilon on white rats and cats under narcosis have been studied.  Cerebrum metabolism induced were determined during the experiment.  It has been established that preliminary administration of picamilon in the dose of 55 mg/kg increased the percentage of animal survival after circulatory hypoxia, promoted reduction and stimulation of glucose and oxygen utilization processes, decreased the-intensity of cerebral blood flow and increased the functional cerebrovascular stability towards acute hypotension, influenced positively on cerebrovescular autoregulatory reactions in the postischemic period.

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