Picamilon influence on Brain Edema

[Article in Russian]

Medical Institute, Krupskaya St., 
28, Smolensk, 214019, USSR

Abstract

The influence of the GABA-derivative - picamilon - on toxic and traumatic brain edema course has been studied in experiments on animals.  The drug activity was estimated by its influence on water lactate and pyruvate content in the brain tissue and density of the latter.  The results have been presented in comparison with those for piracetam.  Picamilon was found to be able of suppressing brain edema development. But this action is weakly pronounced and only by application of high doses of the drug.  Piracetam has no advantages in this action comparing to picamilon and in some indices even yields to picamilon.

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